(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

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Chemical Name:(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal
CAS No.:154783-05-8
Molecular Formula:C₃₃H₅₆O₄Si₂
Molecular Weight:572.976
Hs Code.:

Synonyms:(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

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Chemical Property of (E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

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Technology Process of (E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

There total 3 articles about (E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 154783-02-5
3-<4-pentyl-2,6-bis(tert-butyldimethylsilyloxy)phenyl>-4-<3'-(1'-hydroxy-3',4'-butenyl)>cyclohexane-1-one

: 154783-05-8
(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; -78 deg C, 15 min, then 23 deg C, 12 h;
DOI:10.1016/S0040-4020(01)86983-0

Reference yield:

: 154783-00-3
(3R,4R)-3-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-(1-iodo-1-methyl-ethyl)-cyclohexanone

: 154783-05-8
(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

Guidance literature:: Multi-step reaction with 3 steps

1: DBU / benzene / 2 h / 23 °C

2: 1.) 2,6-diphenylphenol, 1.6M trimethylaluminum / 1.) CH₂Cl₂, toluene, 23 deg C, 2.) 0 deg C, 1 h, 3.) CH₂Cl₂, 2 h

3: 85 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / -78 deg C, 15 min, then 23 deg C, 12 h

With oxalyl dichloride; (1,1';3',1''-terphenyl)-2'-ol; trimethylaluminum; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; benzene;
DOI:10.1016/S0040-4020(01)86983-0

Reference yield:

: 154783-01-4
3-<4-pentyl-2,6-bis(tert-butyldimethylsilyloxy)phenyl>-4-isopropenycyclohexane-1-one

: 154783-05-8
(E)-3-{(1R,2R)-2-[2,6-Bis-(tert-butyl-dimethyl-silanyloxy)-4-pentyl-phenyl]-4-oxo-cyclohexyl}-but-2-enal

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 2,6-diphenylphenol, 1.6M trimethylaluminum / 1.) CH₂Cl₂, toluene, 23 deg C, 2.) 0 deg C, 1 h, 3.) CH₂Cl₂, 2 h

2: 85 percent / oxalyl chloride, DMSO, Et₃N / CH₂Cl₂ / -78 deg C, 15 min, then 23 deg C, 12 h

With oxalyl dichloride; (1,1';3',1''-terphenyl)-2'-ol; trimethylaluminum; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)86983-0