1H-Indole-6-carboxylicacid,3-methyl-(9CI)

Base Information

• Chemical Name: 1H-Indole-6-carboxylicacid,3-methyl-(9CI)
• CAS No.: 201286-69-3
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.187
• Hs Code.: 2933990090
• Mol file: 201286-69-3.mol

Synonyms:3-Methyl-1H-indole-6-carboxylicacid; 3-Methylindole-6-carboxylic acid

Chemical Property of 1H-Indole-6-carboxylicacid,3-methyl-(9CI)

Chemical Property:

• PSA: 53.09000
• LogP: 2.17450
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-1H-indole-6-carboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-6-carboxylicacid,3-methyl-(9CI)

There total 6 articles about 1H-Indole-6-carboxylicacid,3-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 3-methylindole-6-carboxylate (184151-49-3) → 3-methyl-1H-indole-6-carboxylic acid (201286-69-3)

Guidance literature:

With lithium hydroxide; In methanol; at 70 ℃;

DOI:10.1016/S0960-894X(98)00324-2

Reference yield:

methyl 3-formyl-6-indolecarboxylate (133831-28-4) → 3-methyl-1H-indole-6-carboxylic acid (201286-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) p-toluenesulfonic acid, p-toluenesulfonyl hydrazide, sulfolane, 2.) NaCNBH₃ / 1.) DMF, 100 deg C, 2.) DMF, 100 deg C, 2 h

2: 90 percent / aq. LiOH / methanol / 70 °C

With sulfolane; lithium hydroxide; sodium cyanoborohydride; toluene-4-sulfonic acid; toluene-4-sulfonic acid hydrazide; In methanol;

DOI:10.1016/S0960-894X(98)00324-2

Reference yield:

indole-6-carboxylic acid methyl ester (50820-65-0) → 3-methyl-1H-indole-6-carboxylic acid (201286-69-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 0.5 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 1 h / 50 °C / Inert atmosphere

3: water; lithium hydroxide / methanol / 2 h / 50 °C

With borane-THF; water; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol;

upstream raw materials:

methyl 3-methylindole-6-carboxylate

methyl 3-formyl-6-indolecarboxylate

indole-6-carboxylic acid methyl ester

6-bromo-3-methyl-1H-indole