2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

Base Information

Chemical Name:2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one
CAS No.:170104-99-1
Molecular Formula:C₂₄H₁₉Br₂N₃O₄
Molecular Weight:573.241
Hs Code.:

Synonyms:2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

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Chemical Property of 2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

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Technology Process of 2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

There total 7 articles about 2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 104-63-2
N-Benzylethanolamine

: 170104-96-8
5,8-Dibromo-2-bromomethyl-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

: 170104-99-1
2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

Guidance literature:: In N,N-dimethyl-formamide; at 25 ℃; for 5h;
DOI:10.1055/s-1999-3494

Reference yield:

: 6-bromo-1-(2-carboxy-3-methoxy)phenyl-3-methyl-1H-indazole sodium salt

: 170104-99-1
2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / K₂CO₃ / methanol; dimethylformamide / 2 h / 50 °C

2: 65 percent / NBS, AIBN / 1,2-dichloro-ethane / 1.5 h / Heating

3: 1.) CF₃SO₃H, 2.) HBr, ACOH / 1.) 100 deg C, 4 h, 2.) 70 deg C, 4 h

4: 91 percent / Br₂ / 1,2-dichloro-ethane / 2 h / 25 °C

5: 89 percent / n-Bu₄NHSO₄, PhI(OAc)2, TFA, AcOH / 2 h / 40 °C

6: 90 percent / n-Bu₄NBH(OAc)3 / CH₂Cl₂ / 2 h / 25 °C

7: 70 percent / dimethylformamide / 5 h / 25 °C

With N-Bromosuccinimide; tetrabutylammonium triacetoxyborohydride; 2,2'-azobis(isobutyronitrile); trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; hydrogen bromide; bromine; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1999-3494

Reference yield:

: 238756-60-0
Methyl 2-(6-bromo-3-methyl-1H-indazol-1-yl)-6-methoxybenzoate

: 170104-99-1
2-<<(1-Benzyl-2-hydroxyethyl)amino>methyl>-5,8-dibromo-7,10-dihydroxy-6H-pyrazolo<4,5,1-de>acridin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / NBS, AIBN / 1,2-dichloro-ethane / 1.5 h / Heating

2: 1.) CF₃SO₃H, 2.) HBr, ACOH / 1.) 100 deg C, 4 h, 2.) 70 deg C, 4 h

3: 91 percent / Br₂ / 1,2-dichloro-ethane / 2 h / 25 °C

4: 89 percent / n-Bu₄NHSO₄, PhI(OAc)2, TFA, AcOH / 2 h / 40 °C

5: 90 percent / n-Bu₄NBH(OAc)3 / CH₂Cl₂ / 2 h / 25 °C

6: 70 percent / dimethylformamide / 5 h / 25 °C

With N-Bromosuccinimide; tetrabutylammonium triacetoxyborohydride; 2,2'-azobis(isobutyronitrile); trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; hydrogen bromide; bromine; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1999-3494