Technology Process of 4-benzyloxy-3-dodecyl-2-methylquinolin-6-ol
There total 7 articles about 4-benzyloxy-3-dodecyl-2-methylquinolin-6-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; water;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.3987/COM-10-S(E)9
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid / ethanol / 42 h / 75 °C / Inert atmosphere; Molecular sieve; solid phase reaction
2.1: diphenylether / 1 h / 260 °C / Inert atmosphere
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane; dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere
3.2: 2 h / 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; tetrabutyl ammonium fluoride; acetic acid; diisopropylamine;
In
tetrahydrofuran; diphenylether; ethanol; hexane; water; dimethyl sulfoxide;
DOI:10.3987/COM-10-S(E)9
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium / ethanol / 6 h / 80 °C / Inert atmosphere
2.1: acetic acid / ethanol / 42 h / 75 °C / Inert atmosphere; Molecular sieve; solid phase reaction
3.1: diphenylether / 1 h / 260 °C / Inert atmosphere
4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane; dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere
4.2: 2 h / 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; water / 3 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; tetrabutyl ammonium fluoride; sodium; acetic acid; diisopropylamine;
In
tetrahydrofuran; diphenylether; ethanol; hexane; water; dimethyl sulfoxide;
DOI:10.3987/COM-10-S(E)9
