(1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one

Base Information

• Chemical Name: (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one
• CAS No.: 104154-99-6
• Molecular Formula: C₁₇H₂₂O₂
• Molecular Weight: 258.36
• Mol file: 104154-99-6.mol

Synonyms:(1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one

Chemical Property of (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one

There total 3 articles about (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(+)-(1R,2S,3R,4S)-2-hydroxy-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>heptane (73440-88-7) → (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one (104154-99-6)

Guidance literature:

With Celite; pyridinium chlorochromate; In dichloromethane; for 14h; Ambient temperature;

Reference yield:

(1R)-(-)-cis-3-hydroxyisoborneol (59599-25-6) → (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one (104154-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / 50 percent NaH in oil / dimethylformamide / 4 h / Ambient temperature

2: 98 percent / PCC, celite / CH₂Cl₂ / 14 h / Ambient temperature

With Celite; sodium hydride; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

benzyl chloride (100-44-7) → (1R,3R,4S)-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>hept-2-one (104154-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / 50 percent NaH in oil / dimethylformamide / 4 h / Ambient temperature

2: 98 percent / PCC, celite / CH₂Cl₂ / 14 h / Ambient temperature

With Celite; sodium hydride; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(+)-(1R,2S,3R,4S)-2-hydroxy-3-benzyloxy-1,7,7-trimethylbicyclo<2.2.1>heptane

(1R)-(-)-cis-3-hydroxyisoborneol

benzyl chloride

Downstream raw materials:

(1R,3S,4S)-3-Benzyloxy-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one