N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

Base Information

Chemical Name:N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide
CAS No.:1268157-60-3
Molecular Formula:C₃₇H₄₁N₄O₇P
Molecular Weight:684.729
Hs Code.:

Synonyms:N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

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Chemical Property of N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

Chemical Property:

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Technology Process of N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

There total 5 articles about N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2566-23-6,34996-91-3,64896-36-2
N-benzoyl-L-tyrosine

: 1268157-60-3
N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine / acetonitrile / 0.17 h / 20 °C

2.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

3.1: tert.-butylhydroperoxide / water; acetonitrile / 0.17 h / 20 °C

4.1: water; acetic acid / tetrahydrofuran / 1 h / 20 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

5.2: 2.17 h / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1H-tetrazole; tert.-butylhydroperoxide; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm101478n

Reference yield:

: 108549-23-1
Dibenzyl N,N-diisopropylphosphoramidite

: 1268157-60-3
N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

2.1: tert.-butylhydroperoxide / water; acetonitrile / 0.17 h / 20 °C

3.1: water; acetic acid / tetrahydrofuran / 1 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 2.17 h / 0 - 20 °C / Inert atmosphere

With 1H-tetrazole; tert.-butylhydroperoxide; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm101478n

Reference yield:

: C₃₆H₄₂NO₆PSi

: 1268157-60-3
N-benzoyl-O-[bis(benzyloxy)phosphoryl]-N'-[3-(2-oxotetrahydropyrimidin-1(2H)-yl)propyl]-Ltyrosinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butylhydroperoxide / water; acetonitrile / 0.17 h / 20 °C

2.1: water; acetic acid / tetrahydrofuran / 1 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 2.17 h / 0 - 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; water; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm101478n