C₉H₇⁽²⁾HF₃NO

Base Information

• Chemical Name: C₉H₇⁽²⁾HF₃NO
• CAS No.: 169214-30-6
• Molecular Formula: C₉H₈F₃NO
• Molecular Weight: 204.156
• Mol file: 169214-30-6.mol

Synonyms:C₉H₇⁽²⁾HF₃NO

Chemical Property of C₉H₇⁽²⁾HF₃NO

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₉H₇⁽²⁾HF₃NO

There total 3 articles about C₉H₇⁽²⁾HF₃NO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2'-2H]acetanilide (169214-12-4) + Umemoto's reagent → C9H7(2)HF3NO (169214-30-6)

Guidance literature:

With copper diacetate; palladium diacetate; Trimethylacetic acid; In 1,2-dichloro-ethane; at 110 ℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/ol302814x

Reference yield:

Acetanilid (103-84-4) → C9H7(2)HF3NO (169214-30-6)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 1 h / 120 °C / Sealed tube; Inert atmosphere

2: sodium borodeuteride / d⁽⁴⁾-methanol / 2 h / 20 °C

3: palladium diacetate; copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube

With sodium borodeuteride; copper diacetate; palladium diacetate; Trimethylacetic acid; In d⁽⁴⁾-methanol; 1,2-dichloro-ethane; toluene;

DOI:10.1021/ol302814x

Reference yield:

di-μ-acetato-bis(2-acetaminophenyl-2C,O) dipalladium(II) → C9H7(2)HF3NO (169214-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium borodeuteride / d⁽⁴⁾-methanol / 2 h / 20 °C

2: palladium diacetate; copper diacetate; Trimethylacetic acid / 1,2-dichloro-ethane / 12 h / 110 °C / Inert atmosphere; Schlenk technique; Sealed tube

With sodium borodeuteride; copper diacetate; palladium diacetate; Trimethylacetic acid; In d⁽⁴⁾-methanol; 1,2-dichloro-ethane;

DOI:10.1021/ol302814x

upstream raw materials:

Acetanilid

[2'-²H]acetanilide