{2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester
• CAS No.: 863483-03-8
• Molecular Formula: C₂₅H₃₉N₃O₄
• Molecular Weight: 445.602
• Mol file: 863483-03-8.mol

Synonyms:{2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Chemical Property of {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

There total 10 articles about {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-amino-2-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-propane-1,3-diol; hydrochloride + di-tert-butyl dicarbonate (24424-99-5) → {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester (863483-03-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 50 ℃; for 12h;

DOI:10.1016/j.bmcl.2005.05.097

Reference yield:

{2,2-dimethyl-5-[5-(4-oct-1-ynyl-phenyl)-1H-imidazol-2-yl]-[1,3]dioxan-5-yl}-carbamic acid tert-butyl ester (863483-02-7) → {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester (863483-03-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C

2: 87 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C

3: 68 percent / aq. NaHCO₃ / tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.05.097

Reference yield:

{5-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-[1,3]dioxan-5-yl}-carbamic acid tert-butyl ester (654067-57-9) → {2-hydroxy-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester (863483-03-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / Ph₃P; CuI; DIEA / Pd(dba)2 / tetrahydrofuran / 12 h / 20 °C

2: 100 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C

3: 87 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C

4: 68 percent / aq. NaHCO₃ / tetrahydrofuran / 12 h / 50 °C

With hydrogenchloride; copper(l) iodide; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; 1: Sonogashira coupling;

DOI:10.1016/j.bmcl.2005.05.097

upstream raw materials:

di-tert-butyl dicarbonate

{5-[5-(4-iodo-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-[1,3]dioxan-5-yl}-carbamic acid tert-butyl ester

{2,2-dimethyl-5-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-[1,3]dioxan-5-yl}-carbamic acid tert-butyl ester

{2,2-dimethyl-5-[5-(4-oct-1-ynyl-phenyl)-1H-imidazol-2-yl]-[1,3]dioxan-5-yl}-carbamic acid tert-butyl ester

Downstream raw materials:

{1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(di-tert-butoxy-thiophosphoryloxy)-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

{1-(tert-butyl-dimethyl-silanyloxymethyl)-2-(di-tert-butoxy-phosphoryloxy)-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester

{2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-1-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-ethyl}-carbamic acid tert-butyl ester