biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

Base Information

Chemical Name:biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide
CAS No.:863401-89-2
Molecular Formula:C₂₄H₂₅N₃O
Molecular Weight:371.482
Hs Code.:

Synonyms:biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

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Chemical Property of biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

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Technology Process of biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

There total 5 articles about biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 863401-88-1
(1-{4-[(biphenyl-4-carbonyl)-amino]-phenyl}-pyrrolidin-3-yl)-methyl-carbamic acid tert-butyl ester

: 863401-89-2
biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 4h;
DOI:10.1016/j.bmcl.2005.05.130

Reference yield:

: 863401-75-6
methyl-[1-(4-nitro-phenyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

: 863401-89-2
biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 5 h

2: 74 percent / Et₃N / CH₂Cl₂ / 2 h

3: 100 percent / TFA / CH₂Cl₂ / 4 h

With hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2005.05.130

Reference yield:

: 169750-01-0,172478-00-1
3-<(t-butyloxycarbonyl)methylamino>-pyrrolidine

: 863401-89-2
biphenyl-4-carboxylic acid [4-(3-methylamino-pyrrolidin-1-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 1 h / 20 °C

2: 100 percent / H₂ / Pd/C / tetrahydrofuran / 5 h

3: 74 percent / Et₃N / CH₂Cl₂ / 2 h

4: 100 percent / TFA / CH₂Cl₂ / 4 h

With hydrogen; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2005.05.130