(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

Base Information

Chemical Name:(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide
CAS No.:1605327-86-3
Molecular Formula:C₂₆H₂₅FN₈O₃S
Molecular Weight:548.601
Hs Code.:

(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

Synonyms:(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

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Chemical Property of (S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

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Technology Process of (S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

There total 9 articles about (S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 710348-96-2
N-(3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanesulfonamide

: 1605328-72-0
(S)-2-(1-((6-amino-5-bromopyrimidin-4-yl)amino)ethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 1605327-86-3
(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1403943-08-7
(S)-2-(1-aminoethyl)-5-methyl-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 1605327-86-3
(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; cesium fluoride / tert-butyl alcohol / 40 h / 140 °C / Sealed tube

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield:

: 40611-69-6
methyl 3-methyl-1H-pyrrole-2-carboxylate

: 1605327-86-3
(S)-N-(3-(4-amino-6-((1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl)amino)pyrimidin-5-yl)-5-fluorophenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / methanol / 60 °C

2.1: oxalyl dichloride / dichloromethane / 3 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4.1: sodium hydroxide; ammonium chloride; ammonium hydroxide; sodium hypochlorite / diethyl ether; tert-butyl methyl ether / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 0 - 20 °C

6.1: triethylamine; triphenylphosphine; bromine / dichloromethane / 2 h / 60 °C

6.2: 32 h / 100 °C

7.1: trifluoroacetic acid / dichloromethane / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; cesium fluoride / tert-butyl alcohol / 40 h / 140 °C / Sealed tube

9.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / water; 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

With ammonium hydroxide; sodium hypochlorite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; bromine; ammonium chloride; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cesium fluoride; trifluoroacetic acid; sodium hydroxide; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; tert-butyl alcohol;