(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one
CAS No.:955406-67-4
Molecular Formula:C₃₀H₃₀Cl₂F₃N₃O₅S
Molecular Weight:672.553
Hs Code.:

Synonyms:(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

There total 6 articles about (R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850568-54-6
(4-(tert-butoxycarbonyl)phenyl)boronic acid

: 955406-41-4
trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955406-40-3
trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-3-ylmethyl]-phenyl ester

: 955406-66-3
(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(1-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-pyrrolidin-2-one

: 955406-67-4
(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; at 60 - 80 ℃; for 1h;

Reference yield:

: 955373-73-6
(R)-4-((R)-4-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-benzyloxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 955406-67-4
(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 13 h / 20 - 50 °C

2: hydrogen / 10 % Pd(OH)2/C / ethanol / 3 h / 20 °C / 2585.81 Torr

3: pyridine / dichloromethane / 0.83 h / 0 - 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 60 - 80 °C

With pyridine; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 % Pd(OH)2/C; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 955373-72-5
(R)-4-benzyl-3-[(S)-2-(4-benzyloxy-2,6-dichloro-benzyl)-pent-4-enoyl]-oxazolidin-2-onecf

: 955406-67-4
(R)-3-(3,5-dichloro-4'-t-butoxycarbonyl-biphenyl-4-ylmethyl)-1-(2-trifluoromethanesulfonyl-4,5,6,7-tetrahydro-2H-indazol-4-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium periodate / osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 13 h / 20 - 50 °C

3: hydrogen / 10 % Pd(OH)2/C / ethanol / 3 h / 20 °C / 2585.81 Torr

4: pyridine / dichloromethane / 0.83 h / 0 - 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 60 - 80 °C

With pyridine; sodium periodate; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 % Pd(OH)2/C; In tetrahydrofuran; ethanol; dichloromethane; water; 1,2-dichloro-ethane; tert-butyl alcohol;