(S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

Base Information

Chemical Name:(S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one
CAS No.:1429229-25-3
Molecular Formula:C₁₅H₁₆N₂O₂
Molecular Weight:256.304
Hs Code.:

Synonyms:(S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

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Chemical Property of (S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

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Technology Process of (S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

There total 2 articles about (S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₆N₂O₅

: 1429229-25-3
(S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

Guidance literature:: C₂₀H₂₆N₂O₅; With hydrogenchloride; acetic acid; In water; at 0 - 20 ℃; for 12h;

With sodium hydrogencarbonate; In water; for 3h; pH=Ca. 7; Reflux;
DOI:10.1016/j.tetlet.2013.02.067

Reference yield:

: 14003-16-8
5-methylfurfurylamine

: 1429229-25-3
(S)-4-(4-hydroxybenzyl)-6-methyl-1,2-dihydropyrrolo[1,2-a]pyrazin-3(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 1 h / -15 °C

2.1: hydrogenchloride; acetic acid / water / 12 h / 0 - 20 °C

2.2: 3 h / pH Ca_. 7 / Reflux

With 4-methyl-morpholine; hydrogenchloride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;
DOI:10.1016/j.tetlet.2013.02.067