(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

Base Information

Chemical Name:(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane
CAS No.:113490-13-4
Molecular Formula:C₃₀H₄₈O₄Si
Molecular Weight:500.794
Hs Code.:

Synonyms:(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

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Chemical Property of (3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

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Technology Process of (3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

There total 7 articles about (3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113490-12-3
(3R,7S)-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octan-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 113490-13-4
(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

Guidance literature:: With dmap; triethylamine; 1-(Trimethylsilyl)imidazole; In dichloromethane; at 0 ℃; Yield given;
DOI:10.1021/jo00244a017

Reference yield:

: 113490-08-7
(2S,6R)-2,6-dimethyl-1-<(2'-methoxyethoxy)methoxy>-heptan-7-ol

: 113490-13-4
(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / pyridine, 4-(dimethylamino)pyridine / CH₂Cl₂ / Ambient temperature

2: 90 percent / 18-crown-6 / acetonitrile / 40 h / Heating

3: 100 percent / diisobutylammonium hydride / hexane / 1.) -78 deg C, 30 min, 2.) room temperature, 4 h

4: 77 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

5: 1.) 4-(dimethylamino)pyridine, triethylamine, 2.) (trimethylsilyl)imidazole / CH₂Cl₂ / 0 °C

With pyridine; dmap; lithium aluminium tetrahydride; Diisobutylammonium hydride; 18-crown-6 ether; triethylamine; 1-(Trimethylsilyl)imidazole; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jo00244a017

Reference yield:

: 113490-11-2
(3R,7S)-8-(2-Methoxy-ethoxymethoxy)-3,7-dimethyl-octanal

: 113490-13-4
(3R,7S)-1-<(tert-butyldiphenylsilyl)oxy>-3,7-dimethyl-8-<(2'-methoxyethoxy)methoxy>octane

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) 4-(dimethylamino)pyridine, triethylamine, 2.) (trimethylsilyl)imidazole / CH₂Cl₂ / 0 °C

With dmap; lithium aluminium tetrahydride; triethylamine; 1-(Trimethylsilyl)imidazole; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00244a017