C₄₂H₄₁ClF₂O₆

Base Information

Chemical Name:C₄₂H₄₁ClF₂O₆
CAS No.:1369406-03-0
Molecular Formula:C₄₂H₄₁ClF₂O₆
Molecular Weight:715.234
Hs Code.:

C<sub>42</sub>H<sub>41</sub>ClF<sub>2</sub>O<sub>6</sub>

Synonyms:C₄₂H₄₁ClF₂O₆

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Chemical Property of C₄₂H₄₁ClF₂O₆

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Technology Process of C₄₂H₄₁ClF₂O₆

There total 12 articles about C₄₂H₄₁ClF₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 461432-23-5
4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene

: 1369405-80-0
(3R,4R,6R)-3,4-bis(benzyloxy)-6-((benzyloxy)methyl)-5,5-difluorotetrahydro-2H-pyran-2-one

: 1369406-03-0
C₄₂H₄₁ClF₂O₆

Guidance literature:: 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 1h; Inert atmosphere;

(3R,4R,6R)-3,4-bis(benzyloxy)-6-((benzyloxy)methyl)-5,5-difluorotetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; toluene; at -98 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran; hexane; toluene; at -98 - 20 ℃; stereoselective reaction;
DOI:10.1016/j.tetlet.2012.02.062

Reference yield:

: 1369405-72-0
(2S,3R)-3-(benzyloxy)-4,4-difluorohex-5-ene-1,2-diyl diacetate

: 1369406-03-0
C₄₂H₄₁ClF₂O₆

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol; potassium carbonate / 8 h / 20 °C

2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

3.2: 0 - 20 °C

4.1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / water; acetone / 48 h / 20 °C

5.1: di(n-butyl)tin oxide / toluene / 6 h / Reflux

5.2: 16 h / Reflux

6.1: tetrabutyl ammonium fluoride / 0 - 20 °C

7.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid / dichloromethane / 0 - 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 1 h / -78 °C / Inert atmosphere

8.2: 3 h / -98 °C

8.3: -98 - 20 °C

With methanol; dmap; potassium osmate(VI) dihydrate; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene; mineral oil;
DOI:10.1016/j.tetlet.2012.02.062

Reference yield:

: 1369405-77-5
(2R,4R,5S)-1,4,5-tris(benzyloxy)-6-((tert-butyldimethylsilyl)oxy)-3,3-difluorohexan-2-ol

: 1369406-03-0
C₄₂H₄₁ClF₂O₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / 0 - 20 °C

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid / dichloromethane / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane; toluene / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -98 °C

3.3: -98 - 20 °C

With n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1016/j.tetlet.2012.02.062