N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine

Base Information

• Chemical Name: N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine
• CAS No.: 675103-18-1
• Molecular Formula: C₂₄H₃₅N₅
• Molecular Weight: 393.575

Synonyms:N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine

Chemical Property of N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine

Chemical Property:

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Technology Process of N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine

There total 7 articles about N¹-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N⁴-phenyl-benzene-1,2,4-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N4-cyclohexylmethyl-2-(4-methyl-piperazin-1-yl)-5-nitro-N1-phenyl-benzene-1,4-diamine (675103-17-0) → N1-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N4-phenyl-benzene-1,2,4-triamine (675103-18-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2006.09.014

Reference yield:

1-methyl-piperazine (109-01-3) → N1-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N4-phenyl-benzene-1,2,4-triamine (675103-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / Hunig's Base / dimethylformamide / 24 h / 100 °C

2: 75 percent / H₂ / Pd/C / ethyl acetate / 16 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.09.014

Reference yield:

2,4-difluoro-5-nitro-N-phenylaniline (675103-15-8) → N1-cyclohexylmethyl-5-(4-methyl-piperazin-1-yl)-N4-phenyl-benzene-1,2,4-triamine (675103-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / dimethylformamide / 14 h / 20 °C

2: 64 percent / Hunig's Base / dimethylformamide / 24 h / 100 °C

3: 75 percent / H₂ / Pd/C / ethyl acetate / 16 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.09.014

upstream raw materials:

N⁴-cyclohexylmethyl-2-(4-methyl-piperazin-1-yl)-5-nitro-N¹-phenyl-benzene-1,4-diamine

1-methyl-piperazine

2,4-difluoro-5-nitro-N-phenylaniline

N⁴-cyclohexylmethyl-2-fluoro-5-nitro-N¹-phenyl-benzene-1,4-diamine

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