{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

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Chemical Name:{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone
CAS No.:1255303-61-7
Molecular Formula:C₃₁H₃₇N₃O₆
Molecular Weight:547.651
Hs Code.:

Synonyms:{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

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Chemical Property of {4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

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Technology Process of {4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

There total 5 articles about {4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 276862-76-1,186393-21-5
(3S,4S)-pyrrolidine-3,4-diol hydrochloride

: 1255305-51-1
2-(2-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-yloxy)ethyl methanesulfonate

: 1255303-61-7
{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

Guidance literature:: (3S,4S)-pyrrolidine-3,4-diol hydrochloride; With sodium hydroxide; In propan-1-ol; water; at 20 ℃; for 1h;

2-(2-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-yloxy)ethyl methanesulfonate; In propan-1-ol; water; at 100 ℃; for 5h;

Reference yield:

: 1255305-47-5
1-(4-ethylbenzyloxy)-4-iodo-2-methoxybenzene

: 1255303-61-7
{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc / tetrahydrofuran / 1.17 h / 20 - 70 °C / Inert atmosphere

1.2: 3 h / 20 °C

2.1: ethanol / 3 h / 80 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 11 h / 80 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

6.1: sodium hydroxide / propan-1-ol; water / 1 h / 20 °C

6.2: 5 h / 100 °C

With chloro-trimethyl-silane; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylene dibromide; triethylamine; lithium chloride; sodium hydroxide; zinc; In tetrahydrofuran; propan-1-ol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1467-05-6
4-ethylbenzylchloride

: 1255303-61-7
{4-[2-((3S,4S)-3,4-Dihydroxypyrrolidin-1-yl)ethoxy]pyridin-2-yl}-{3-[4-(4-ethylbenzyloxy)-3-methoxyphenyl]azetidin-1-yl}-methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 - 80 °C

2.1: chloro-trimethyl-silane; ethylene dibromide; lithium chloride; zinc / tetrahydrofuran / 1.17 h / 20 - 70 °C / Inert atmosphere

2.2: 3 h / 20 °C

3.1: ethanol / 3 h / 80 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 11 h / 80 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

7.1: sodium hydroxide / propan-1-ol; water / 1 h / 20 °C

7.2: 5 h / 100 °C

With chloro-trimethyl-silane; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethylene dibromide; triethylamine; lithium chloride; sodium hydroxide; zinc; In tetrahydrofuran; propan-1-ol; ethanol; water; N,N-dimethyl-formamide;