(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

Base Information

Chemical Name:(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate
CAS No.:1310683-99-8
Molecular Formula:C₂₄H₂₂ClF₃N₄O₄
Molecular Weight:522.911
Hs Code.:

Synonyms:(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

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Chemical Property of (R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

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Technology Process of (R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

There total 7 articles about (R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1310684-00-4
C₁₆H₁₉N₃O₃

: 16588-69-5
4-chloro-2-trifluoromethylphenylisocyanate

: 1310683-99-8
(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.058

Reference yield:

: 1310683-94-3
(R)-3-hydroxymethyl-5-methyl-1,3-dihydrobenzo[e][1,4]diazepin-2-one

: 1310683-99-8
(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 12 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / Inert atmosphere

3.1: lithium hydroxide / methanol; water / 0 - 20 °C

4.1: HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

6.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.058

Reference yield:

: 1310683-96-5
(R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-5-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 1310683-99-8
(R)-(1-(2-(allylamino)-2-oxoethyl)-5-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)methyl (4-chloro-2-(trifluoromethyl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / Inert atmosphere

2.1: lithium hydroxide / methanol; water / 0 - 20 °C

3.1: HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

5.1: dichloromethane / 5 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.02.058