N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine

Base Information

• Chemical Name: N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine
• CAS No.: 152838-39-6
• Molecular Formula: C₃₁H₄₁N₅O₇
• Molecular Weight: 595.696

Synonyms:N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine

Chemical Property of N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine

Chemical Property:

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Technology Process of N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine

There total 7 articles about N⁶-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

6-<(tetrahydro-2H-pyran-2-yl)oxy>hexyl toluene-4-sulfonate (63294-76-8) + N-6-benzoyl-2',3'-O-isopropylideneadenosine (39947-04-1) → N6-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine (152838-39-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

DOI:10.1002/hlca.19930760623

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → N6-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine (152838-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / TsOH / tetrahydrofuran / 0 deg C, 1 h, RT, 1 h

2: 79 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

3: 87 percent / NaH / dimethylformamide / 2 h / 50 °C

With pyridine; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19930760623

Reference yield:

1,6-hexanediol (629-11-8) → N6-benzoyl-2',3'-O-isopropylidene-5'-O-<6-(tetrahydro-2H-pyran-2-yl)hexyl>adenosine (152838-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / TsOH / tetrahydrofuran / 0 deg C, 1 h, RT, 1 h

2: 79 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

3: 87 percent / NaH / dimethylformamide / 2 h / 50 °C

With pyridine; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19930760623

upstream raw materials:

6-<(tetrahydro-2H-pyran-2-yl)oxy>hexyl toluene-4-sulfonate

N-6-benzoyl-2',3'-O-isopropylideneadenosine

3,4-dihydro-2H-pyran

6-(tetrahydro-2H-pyranyloxy)hexan-1-ol

Downstream raw materials:

5'-O-<6-<(tol-4-yl)sulfonyloxy>hexyl>adenosine

2',3'-O-isopropylidene-5'-O-<6-<(tol-4-yl)sulfonyloxy>hexyl>adenosine

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