3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

Base Information

Chemical Name:3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one
CAS No.:82415-25-6
Molecular Formula:C₄₉H₆₆O₇Si
Molecular Weight:795.144
Hs Code.:

3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

Synonyms:3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

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Chemical Property of 3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

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Technology Process of 3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

There total 4 articles about 3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(methoxymethyleneoxy)-2,5-dimethylbenzoic acid

: 82415-25-6
3-{(1E,5E)-(R)-7-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH, t-BuLi / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C to -50 deg C

2: NaH, t-BuLi / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja00381a049

Reference yield:

: 4-(methoxymethyleneoxy)-2,5-dimethylbenzoic acid

: 82415-25-6
3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH, t-BuLi / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C to -50 deg C

2: NaH, t-BuLi / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 deg C

With tert.-butyl lithium; sodium hydride; In tetrahydrofuran;
DOI:10.1021/ja00381a049

Reference yield:

: 82415-10-9
2-Ethyl-4-methoxymethoxy-5-methyl-benzoic acid

: 82415-24-5,104759-57-1,104759-58-2
(2E,6E)-(R)-8-[(2R,4S,6R,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-4,6-dimethyl-octa-2,6-dienal

: 82415-25-6
3-{(1E,5E)-(R)-7-[(2R,4S,6R,8R,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

: 82415-25-6
3-{(1E,5E)-(R)-7-[(2R,4S,6R,8S,9S)-4-(tert-Butyl-diphenyl-silanyloxy)-8,9-dimethyl-1,7-dioxa-spiro[5.5]undec-2-yl]-3,5-dimethyl-hepta-1,5-dienyl}-6-methoxymethoxy-4,7-dimethyl-isochroman-1-one

Guidance literature:: With tert.-butyl lithium; sodium hydride; In tetrahydrofuran; Yield given. Yields of byproduct given. Title compound not separated from byproducts; 1.) -78 deg C, 1 h, 2.) -78 deg C;
DOI:10.1021/ja00381a049