(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

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Chemical Name:(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)
CAS No.:1401468-89-0
Molecular Formula:C₇₂H₉₂N₅O₁₆*I
Molecular Weight:1410.45
Hs Code.:

(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

Synonyms:(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

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Chemical Property of (3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

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Technology Process of (3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

There total 3 articles about (3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1310077-21-4
benzyl 2-(S)-((tert-butoxycarbonyl)amino)-6-iodo-hexanoate

: 1401468-84-5
((2S,2'S)-benzyl 4,4'-(4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonyl amino)-5-oxopent-1-ynyl)pyridine-3,5-diyl)bis(2-(tert-butoxycarbonylamino)butanoate))

: 1401468-89-0
(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

Guidance literature:: In nitromethane; at 60 - 80 ℃; for 48.5h; Inert atmosphere; Molecular sieve;
DOI:10.1016/j.tetlet.2012.08.084

Reference yield:

: 625-92-3
3,5-dibromopyridine

: 1401468-89-0
(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -85 °C / Inert atmosphere; Molecular sieve

1.2: 4 h / -78 °C / Inert atmosphere; Molecular sieve

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere; Molecular sieve

3.1: zinc; chloro-trimethyl-silane / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Molecular sieve

3.2: 24 h / 40 - 50 °C / Inert atmosphere; Molecular sieve

4.1: nitromethane / 48.5 h / 60 - 80 °C / Inert atmosphere; Molecular sieve

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; n-butyllithium; chloro-trimethyl-silane; trifuran-2-yl-phosphane; diisopropylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; nitromethane; hexane; N,N-dimethyl-formamide; 1.1: |Negishi Coupling / 1.2: |Negishi Coupling / 2.1: |Sonogashira Cross-Coupling / 3.1: |Negishi Coupling / 3.2: |Negishi Coupling;
DOI:10.1016/j.tetlet.2012.08.084

Reference yield:

: 1214383-75-1
3,5-dibromo-4-iodopyridine

: 1401468-89-0
(3,5-bis((S)-4-(benzyloxy)-3-(tert-butoxycarbonylamino)-4-oxobutyl)-4-((S)-5-(benzyloxy)-4-(tert-butoxycarbonylamino)-5-oxopent-1-ynyl)-1-((S)-6-(benzyloxy)-5-(tert-butoxycarbonylamino)-6-oxohexyl)pyridinium iodide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 40 °C / Inert atmosphere; Molecular sieve

2.1: zinc; chloro-trimethyl-silane / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere; Molecular sieve

2.2: 24 h / 40 - 50 °C / Inert atmosphere; Molecular sieve

3.1: nitromethane / 48.5 h / 60 - 80 °C / Inert atmosphere; Molecular sieve

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; chloro-trimethyl-silane; trifuran-2-yl-phosphane; N-ethyl-N,N-diisopropylamine; zinc; In nitromethane; N,N-dimethyl-formamide; 1.1: |Sonogashira Cross-Coupling / 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1016/j.tetlet.2012.08.084