7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

Base Information

Chemical Name:7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one
CAS No.:265324-93-4
Molecular Formula:C₂₅H₂₈ClIN₂O₂
Molecular Weight:550.867
Hs Code.:

7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1<i>H</i>-quinolin-2-one

Synonyms:7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

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Chemical Property of 7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

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Technology Process of 7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

There total 6 articles about 7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: (S)-2-(2-chloroethyl)-1-methylpiperidiine hydrochloride

: 199861-89-7
7-chloro-3-(3,5-dimethylphenyl)-4-hydroxy-6-iodo-1H-quinolin-2-one

: 265324-93-4
7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1016/S0960-894X(00)00024-X

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 265324-93-4
7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: I₂; Ag₂SO₄ / ethanol / 1 h / 20 °C

2: 85 percent / 1,2-dichloro-ethane / 3 h / 80 °C

3: 88 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / 0 °C

4: 60 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

With iodine; potassium carbonate; silver sulfate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1: Iodination / 2: Acylation / 3: Cyclization / 4: Alkylation;
DOI:10.1016/S0960-894X(00)00024-X

Reference yield:

: 131134-77-5
(S)-2-(methoxycarbonylmethyl)piperidine-1-carboxylic acid tert-butyl ester

: 265324-93-4
7-chloro-3-(3,5-dimethyl-phenyl)-6-iodo-4-[2-(1-methyl-piperidin-2-yl)-ethoxy]-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / tetrahydrofuran / Heating

2: 62 percent / SOCl₂; HCl / CHCl₃ / 5 h / 760 Torr / Heating

3: 60 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; 1: Reduction / 2: Chlorination / 3: Alkylation;
DOI:10.1016/S0960-894X(00)00024-X