C₂₇H₂₅F₃N₂O₅

Base Information

Chemical Name:C₂₇H₂₅F₃N₂O₅
CAS No.:1258459-26-5
Molecular Formula:C₂₇H₂₅F₃N₂O₅
Molecular Weight:514.501
Hs Code.:

C<sub>27</sub>H<sub>25</sub>F<sub>3</sub>N<sub>2</sub>O<sub>5</sub>

Synonyms:C₂₇H₂₅F₃N₂O₅

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Chemical Property of C₂₇H₂₅F₃N₂O₅

Chemical Property:

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Technology Process of C₂₇H₂₅F₃N₂O₅

There total 13 articles about C₂₇H₂₅F₃N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-25-4
[2-(3-acetyl-benzyl)-oxazol-4-yl]-carbamic acid tert-butyl ester

: 105919-36-6,120681-07-4
trans-4-(trifluoromethyl)cinnamoyl chloride

: 1258459-26-5
C₂₇H₂₅F₃N₂O₅

Guidance literature:: [2-(3-acetyl-benzyl)-oxazol-4-yl]-carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

trans-4-(trifluoromethyl)cinnamoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 0.583333h; Inert atmosphere;

Reference yield:

: 2062-26-2,87212-84-8,16642-92-5
3-<4'-(trifluoromethyl)phenyl>-2-propenoic acid

: 1258459-26-5
C₂₇H₂₅F₃N₂O₅

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 0.5 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

2.2: 0.58 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1258459-26-5
C₂₇H₂₅F₃N₂O₅

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium tetrafluoroborate / ethylene glycol / 3.5 h / 95 °C / Inert atmosphere

2.1: potassium phosphate monohydrate / palladium diacetate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine / toluene / 6 h / 90 - 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: pH 5 - 6

4.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 1.42 h / 0 °C / Inert atmosphere; Reflux

6.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

9.1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 20 °C / Inert atmosphere

10.1: sodium azide / water; acetone / 1 h / 0 °C / Inert atmosphere

11.1: xylene / 0.08 h / 140 °C / Inert atmosphere

11.2: 0.08 h / 140 °C / Inert atmosphere

12.1: sodium hydride / tetrahydrofuran / 0.58 h / 0 - 20 °C / Inert atmosphere

12.2: 0.58 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium tetrafluoroborate; sodium azide; potassium phosphate monohydrate; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; oxalyl dichloride; hexamethylenetetramine; water; sodium hydride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(ll) bromide; palladium diacetate; N,N-dimethyl-formamide; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In tetrahydrofuran; dichloromethane; water; ethylene glycol; acetone; toluene; xylene; 11.1: Curtius Rearrangement;