1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

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Chemical Name:1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one
CAS No.:1610967-54-8
Molecular Formula:C₁₆H₁₀IN₃O₂
Molecular Weight:403.179
Hs Code.:

Synonyms:1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

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Chemical Property of 1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

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Technology Process of 1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

There total 3 articles about 1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 304-91-6
2-iodoxybenzoic acid

: 1610967-46-8
[(2-azido-4-methylphenyl)ethynyl]trimethylsilane

: 1610967-54-8
1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

Guidance literature:: 2-iodoxybenzoic acid; [(2-azido-4-methylphenyl)ethynyl]trimethylsilane; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

With pyridine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol5012604

Reference yield:

: 1610967-45-7
5-methyl-2-[(trimethylsilyl)ethynyl]aniline

: 1610967-54-8
1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; trifluoroacetic acid; sodium nitrite; In water; acetonitrile; 1.1: |Sandmeyer Reaction / 1.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604

Reference yield:

: 53078-85-6
2-bromo-5-methylaniline

: 1610967-54-8
1-[(2-azido-4-methylphenyl)ethynyl]-1λ3-benzo[d][1,2]iodaoxol-3(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloro bis(acetonitrile) palladium(II); tri-tert-butyl phosphine; copper(l) iodide; diisopropylamine / toluene / 2 h / 50 °C

2.1: trifluoroacetic acid; sodium nitrite / water / 1 h / 0 °C

2.2: 1 h / 0 °C

3.1: trimethylsilyl trifluoromethanesulfonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With dichloro bis(acetonitrile) palladium(II); copper(l) iodide; tri-tert-butyl phosphine; trimethylsilyl trifluoromethanesulfonate; diisopropylamine; trifluoroacetic acid; sodium nitrite; In water; toluene; acetonitrile; 1.1: |Sonogashira Cross-Coupling / 2.1: |Sandmeyer Reaction / 2.2: |Sandmeyer Reaction;
DOI:10.1021/ol5012604