2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

Base Information

Chemical Name:2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate
CAS No.:930283-44-6
Molecular Formula:C₂₂H₁₆Cl₅F₃N₂O₅S
Molecular Weight:654.706
Hs Code.:

Synonyms:2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

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Chemical Property of 2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

Chemical Property:

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Technology Process of 2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

There total 6 articles about 2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 845866-80-0
3,3,3-trifluoropropane-1-sulfonyl chloride

: 930283-43-5
2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-1-(4-hydroxyphenyl)-5-methyl-1H-imidazole-4-carboxylate

: 930283-44-6
2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at -78 - 20 ℃; for 3h;

Reference yield:

: 866598-56-3
ethyl 1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylate

: 930283-44-6
2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; potassium hydroxide / methanol / 2 h / Reflux

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.67 h / 0 - 20 °C

3.2: 1.33 h

4.1: acetic acid; hydrogen bromide / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 5 h / -78 °C

With oxalyl dichloride; water; hydrogen bromide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 930283-44-6
2,2,2-trichloroethyl 2-(2,4-dichlorophenyl)-5-methyl-1-(4-(3,3,3-trifluoropropylsulfonyloxy)phenyl)-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran / 0.17 h

2.2: 67 h / 20 °C

3.1: water; potassium hydroxide / methanol / 2 h / Reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.67 h / 0 - 20 °C

5.2: 1.33 h

6.1: acetic acid; hydrogen bromide / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 5 h / -78 °C

With oxalyl dichloride; ethylmagnesium bromide; water; hydrogen bromide; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861