(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

Base Information

Chemical Name:(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol
CAS No.:1536263-91-8
Molecular Formula:C₃₄H₃₆O₇
Molecular Weight:556.656
Hs Code.:

Synonyms:(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

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Chemical Property of (7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

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Technology Process of (7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

There total 3 articles about (7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₆H₄₀O₁₁S₂

: 1536263-91-8
(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

Guidance literature:: C₃₆H₄₀O₁₁S₂; With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 0.5h;

With boron trichloride methyl sulfide complex; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jf4046396

Reference yield:

: C₃₄H₃₂O₅

: 1536263-91-8
(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

Guidance literature:: C₃₄H₃₂O₅; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 ℃; for 1h;

With water; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1021/jf4046396

Reference yield:

: 1536263-89-4
(7R,7′S,8S,8′R)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

: 1536263-91-8
(7R,7′S,8R,8′S)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.5 h / 20 °C

2.1: sodium iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.5 h / 80 °C

2.2: 1 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf4046396