(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

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Chemical Name:(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one
CAS No.:437713-56-9
Molecular Formula:C₂₄H₂₁BrFNO₃
Molecular Weight:470.338
Hs Code.:

Synonyms:(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

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Chemical Property of (3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

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Technology Process of (3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

There total 2 articles about (3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 190448-80-7
Acetic acid (S)-1-(4-bromo-phenyl)-3-[(2S,3R)-1-(4-fluoro-phenyl)-2-(4-hydroxy-phenyl)-4-oxo-azetidin-3-yl]-propyl ester

: 437713-56-9
(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

Guidance literature:: With lithium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00750-8

Reference yield:

: Acetic acid (S)-1-(4-bromo-phenyl)-5-oxo-5-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-pentyl ester

: 437713-56-9
(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: TiCl₄; iPr₂NEt / CH₂Cl₂

1.2: BSA / toluene

1.3: TBAF

2.1: 56 percent / aq. LiOH / tetrahydrofuran

With lithium hydroxide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(01)00750-8

Reference yield:

: 437713-56-9
(3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one

: (3R,4S)-1-(4-Fluoro-phenyl)-3-[(S)-3-hydroxy-3-(4-iodo-phenyl)-propyl]-4-(4-hydroxy-phenyl)-azetidin-2-one

Guidance literature:: (3R,4S)-3-[(S)-3-(4-Bromo-phenyl)-3-hydroxy-propyl]-1-(4-fluoro-phenyl)-4-(4-hydroxy-phenyl)-azetidin-2-one; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-n-butyltin); In toluene; Heating;

With phosphate buffer; iodobeads; In ethanol; pH=5.8;
DOI:10.1016/S0960-894X(01)00750-8