N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Base Information

Chemical Name:N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide
CAS No.:1638755-24-4
Molecular Formula:C₂₉H₂₃F₂NO₃S
Molecular Weight:503.569
Hs Code.:

Synonyms:N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Suppliers and Price of N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Chemical Property:

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Technology Process of N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

There total 5 articles about N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 68-34-8
phenyl toluenesulfonamide

: 1638754-84-3
1-((2-ethynylphenyl)(methoxy)methyl)-3,5-difluorobenzene

: 1638755-24-4
N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Guidance literature:: phenyl toluenesulfonamide; With pyridine; oxygen; sodium carbonate; copper dichloride; In toluene; at 70 ℃;

1-((2-ethynylphenyl)(methoxy)methyl)-3,5-difluorobenzene; In toluene; at 70 ℃; for 8h; under 760.051 Torr;
DOI:10.1002/chem.201403040

Reference yield:

: 77123-58-1
2-[2-(trimethylsilyl)ethynyl]benzaldehyde

: 1638755-24-4
N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; iodine

1.2: 1 h / -78 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Cooling with ice

2.2: 2 h / 20 °C

3.1: potassium carbonate; methanol / 1 h / 20 °C

4.1: sodium carbonate; copper dichloride; oxygen; pyridine / toluene / 70 °C

4.2: 8 h / 70 °C / 760.05 Torr

With pyridine; methanol; iodine; oxygen; sodium hydride; sodium carbonate; potassium carbonate; magnesium; copper dichloride; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1002/chem.201403040

Reference yield:

: C₁₉H₂₀F₂OSi

: 1638755-24-4
N-((2-((3,5-difluorophenyl)(methoxy)methyl)phenyl)ethynyl)-4-methyl-N-phenylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; methanol / 1 h / 20 °C

2.1: sodium carbonate; copper dichloride; oxygen; pyridine / toluene / 70 °C

2.2: 8 h / 70 °C / 760.05 Torr

With pyridine; methanol; oxygen; sodium carbonate; potassium carbonate; copper dichloride; In toluene;
DOI:10.1002/chem.201403040