cyclopropylpropynoic acid benzyl ester

Base Information

• Chemical Name: cyclopropylpropynoic acid benzyl ester
• CAS No.: 1009603-04-6
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.237
• Mol file: 1009603-04-6.mol

Synonyms:cyclopropylpropynoic acid benzyl ester

Chemical Property of cyclopropylpropynoic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of cyclopropylpropynoic acid benzyl ester

There total 1 articles about cyclopropylpropynoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Cyclopropylacetylene (6746-94-7) + benzyl chloroformate (501-53-1,94274-21-2) → cyclopropylpropynoic acid benzyl ester (1009603-04-6)

Guidance literature:

Cyclopropylacetylene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 10.1667h;

benzyl chloroformate; In tetrahydrofuran; hexane; at -40 ℃; for 10h;

DOI:10.1002/chem.201103697

Reference yield: 99.0%

cyclopropylpropynoic acid benzyl ester (1009603-04-6) + 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) → C16H18O2 (1379654-23-5)

Guidance literature:

With copper diacetate; In methanol; at -78 - 25 ℃; for 3h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201103697

Reference yield: 30.0%

C7H11N2O(1+)*C9H11O3S(1-) (909717-75-5) + cyclopropylpropynoic acid benzyl ester (1009603-04-6) → benzy 2-cyclopropyl-4-(1-hydroxyethyl)pyrazolo[1,5-a]pyridine-3-carboxylate (909717-93-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

DOI:10.1016/j.bmcl.2012.07.088

upstream raw materials:

Cyclopropylacetylene

benzyl chloroformate

Downstream raw materials:

C₁₆H₁₈O₂

benzy 2-cyclopropyl-4-(1-hydroxyethyl)pyrazolo[1,5-a]pyridine-3-carboxylate

2-Cyclopropyl-4-hydroxymethyl-7-methoxypyrazolo[1,5-a]pyridine-3-carboxylic acid benzyl ester