3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

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Chemical Name:3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063
CAS No.:1350766-46-9
Molecular Formula:C₃₇H₄₆N₃O₈
Molecular Weight:660.788
Hs Code.:

Synonyms:3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

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Chemical Property of 3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

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Technology Process of 3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

There total 6 articles about 3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 71645-10-8
N-(1-ylooxy-2,2,6,6-tetramethyl-4-piperidinyloxycarbonyl)-L-phenylalanine

: 162705-07-9
3-amino-deoxycombretastatin A₄

: 1350766-46-9
3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

Guidance literature:: N-(1-ylooxy-2,2,6,6-tetramethyl-4-piperidinyloxycarbonyl)-L-phenylalanine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h;

3-amino-deoxycombretastatin A₄; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmc.2012.12.046

Reference yield:

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 1350766-46-9
3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride; triethylamine / 3 h / 140 °C

2.1: copper; quinoline / 2 h / 140 °C

3.1: acetic acid; zinc / 24 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 °C

4.2: 16 h / 20 °C

With quinoline; acetic anhydride; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In dichloromethane;
DOI:10.1016/j.bmc.2012.12.046

Reference yield:

: 31680-08-7
4-methoxy-3-nitrobenzaldehyde

: 1350766-46-9
3'-N-[N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinylcarbonyl)-L-phenylalaninyl]-amido-AVE8063

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride; triethylamine / 3 h / 140 °C

2.1: copper; quinoline / 2 h / 140 °C

3.1: acetic acid; zinc / 24 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.5 h / 0 °C

4.2: 16 h / 20 °C

With quinoline; acetic anhydride; copper; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In dichloromethane;
DOI:10.1016/j.bmc.2012.12.046