1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol

Base Information

• Chemical Name: 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol
• CAS No.: 146857-51-4
• Molecular Formula: C₉H₁₁NO₅
• Molecular Weight: 213.19
• Mol file: 146857-51-4.mol

Synonyms:1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol

Chemical Property of 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol

There total 5 articles about 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

nitromethane (75-52-5) + vanillin (121-33-5,8014-42-4) → 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol (146857-51-4)

Guidance literature:

With nanosized mesoporous CuO/MgAlOx catalyst; In neat (no solvent); at 27 ℃; for 0.05h; Catalytic behavior; Sonication;

Reference yield: 73.0%

1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethanol (60372-07-8) → 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol (146857-51-4)

Guidance literature:

With formic acid; palladium on activated charcoal; In ethanol; at 18 - 20 ℃; for 2h;

Reference yield:

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) → 1-(3-methoxy-4-hydroxyphenyl)-2-nitroethanol (146857-51-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / KOH, tetrabutylammonium bromide / ethanol / 1 h / 0 °C

2: 73 percent / formic acid / 5percent Pd/C / ethanol / 2 h / 18 - 20 °C

With potassium hydroxide; formic acid; tetrabutylammomium bromide; palladium on activated charcoal; In ethanol;

upstream raw materials:

nitromethane

4-benzoyloxy-3-methoxybenzaldehyde

1-(3-methoxy-4-benzyloxyphenyl)-2-nitroethanol

3-methoxy-4-(phenylmethoxy)benzaldehyde

Refernces

• 1、 Bora, Pranjal P.,Bez, Ghanashyam. "Henry reaction in aqueous media at neutral pH". . p. 2922 - 2929. Retrieved 2013/06/27.