2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

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Chemical Name:2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone
CAS No.:1201789-96-9
Molecular Formula:C₂₉H₂₉N₇O
Molecular Weight:491.596
Hs Code.:

Synonyms:2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

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Chemical Property of 2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

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Technology Process of 2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

There total 5 articles about 2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3-[3-(piperazin-1-yl)phenyl]-6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine hydrochloride

: 60853-81-8
N,N-dimethylaminoacetyl chloride hydrochloride

: 1201789-96-9
2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

Guidance literature:: With pyridine; N-ethyl-N,N-diisopropylamine; for 1.5h; Keller tube; Inert atmosphere;

Reference yield:

: 1201786-75-5
C₁₅H₁₁ClN₄

: 1201789-96-9
2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: potassium tert-butylate / palladium diacetate; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine / 1,4-dioxane / 100 °C / Inert atmosphere

2: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube

4: hydrogenchloride / methanol / 5 h / 55 °C

5: N-ethyl-N,N-diisopropylamine; pyridine / 1.5 h / Keller tube; Inert atmosphere

With pyridine; hydrogenchloride; potassium tert-butylate; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (R)-(-)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 1: Hartwig-Buchwald reaction;

Reference yield:

: 1201786-83-5
6-(pyridin-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine

: 1201789-96-9
2-(dimethylamino)-1-(4-{3-[6-(pyrid-3-yl)-9H-pyrrolo[2,3-b:5,4-c']dipyrid-3-yl]-phenyl}piperazin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / N,N-dimethyl-formamide / 3 h / 20 °C

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 7 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / methanol / 5 h / 55 °C

4: N-ethyl-N,N-diisopropylamine; pyridine / 1.5 h / Keller tube; Inert atmosphere

With pyridine; hydrogenchloride; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;