ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Base Information

• Chemical Name: ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate
• CAS No.: 1240660-27-8
• Molecular Formula: C₂₂H₁₉ClFNO₅
• Molecular Weight: 431.848

Synonyms:ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

Chemical Property of ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

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Technology Process of ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate

There total 1 articles about ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-acetyl-1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indole (1240660-10-9) + oxalic acid diethyl ester (95-92-1) → ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate (1240660-27-8)

Guidance literature:

With sodium methylate; In tetrahydrofuran; at 50 ℃; for 0.0666667h; Microwave irradiation;

DOI:10.1016/j.bmc.2010.06.063

Reference yield: 35.0%

ethyl 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoate (1240660-27-8) → 4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid (1240660-44-9)

Guidance literature:

With methanol; sodium hydroxide; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2010.06.063

upstream raw materials:

3-acetyl-1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indole

oxalic acid diethyl ester

Downstream raw materials:

4-[1-(2-chloro-3-fluorobenzyl)-4-methoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid

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