1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Base Information

Chemical Name:1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone
CAS No.:131911-41-6
Molecular Formula:C₂₉H₃₃FN₂O₃
Molecular Weight:476.591
Hs Code.:

Synonyms:1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

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Chemical Property of 1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

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Technology Process of 1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

There total 5 articles about 1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 58113-30-7
4-(3-chloropropoxy)-3-methoxyacetophenone

: 131911-87-0
2-[(4-Fluoro-phenyl)-piperidin-4-yl-methyl]-pyridine

: 131911-41-6
1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: With potassium carbonate; potassium iodide; In butan-1-ol; Heating;
DOI:10.1021/jm00114a009

Reference yield:

: 109-04-6
2-bromo-pyridine

: 131911-41-6
1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, -65 deg C, 1 h, 2.) THF, hexane, RT, 72 h

2: 57percent aq. HI, phosphorous / acetic acid / 40 h / Heating

3: 62 percent / K₂CO₃, KI / butan-1-ol / Heating

With phosphorus; n-butyllithium; hydrogen iodide; potassium carbonate; potassium iodide; In acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009

Reference yield:

: 25519-78-2
4-(4-fluorobenzoyl)piperidine hydrochloride

: 131911-41-6
1-[4-[3-[4-[(4-fluorophenyl)(2-pyridinyl)methyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / pyridine / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -65 deg C, 1 h, 2.) THF, hexane, RT, 72 h

3: 57percent aq. HI, phosphorous / acetic acid / 40 h / Heating

4: 62 percent / K₂CO₃, KI / butan-1-ol / Heating

With pyridine; phosphorus; n-butyllithium; hydrogen iodide; potassium carbonate; potassium iodide; In acetic acid; butan-1-ol;
DOI:10.1021/jm00114a009