methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

Base Information

Chemical Name:methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate
CAS No.:1164274-05-8
Molecular Formula:C₁₈H₁₅ClN₂O₅
Molecular Weight:374.78
Hs Code.:

Synonyms:methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

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Chemical Property of methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

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Technology Process of methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

There total 2 articles about methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1164273-92-0
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(3-(4-cyanophenyl-amino)-3-oxopropyl)benzoate

: 1164274-05-8
methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jo900278g

Reference yield:

: 811788-14-4
methyl 4,6-bis(tert-butyldimethylsilanyloxy)-2-(2-carboxyethyl)-3-chloro-benzoate

: 873-74-5
4-Aminobenzonitrile

: 1164274-05-8
methyl 3-chloro-2-(3-((4-cyanophenyl)amino)-3-oxopropyl)-4,6-dihydroxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; pyridine / dichloromethane / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h

With pyridine; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2014.05.075