4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol

Base Information

• Chemical Name: 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol
• CAS No.: 630393-56-5
• Molecular Formula: C₃₅H₃₇N₅O₃
• Molecular Weight: 575.71
• Mol file: 630393-56-5.mol

Synonyms:4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol

Chemical Property of 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol

There total 1 articles about 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-hydroxy-3,5-bis{[(2-hydroxybenzyl)pyridin-2-ylmethylamino]methyl}benzyl)isoindole-1,3-dione (630393-55-4) → 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol (630393-56-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1002/ejic.200700383

Reference yield: 50.0%

ammonium hexafluorophosphate + 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol (630393-56-5) + bis(2,2'-bipyridine)(4'-methyl-[2,2'-bipyridine]-4-carboxylic acid)ruthenium(II) bis(hexafluorophosphate) → [Ru((C5H4N)2)2(CH3C5H3NC5H3NC(O)NHCH2C6H2(OH)(CH2N(CH2C5H4N)CH2C6H4OH)2)](2+)*2[PF6](1-)=C67H61F12N11O4P2Ru

Guidance literature:

With thionyl chloride; triethylamine; In acetonitrile; Ru complex in SOCl2 heated under reflux for 2 h, evapd. under vac., dry solid dissolved in MeCN, cooled on ice bath, NH2CH2C6H2(OH)(CH2N(CH2C5H3N)CH2C6H4OH)2 and Et3N added, stirred under Ar and allowed to reach roomtemp. overnight; chromy. (silica gel, MeCN/H2O/satd. KNO3 (94/4/2)), evapn., dissolved inMeOH, pptn. by addn. of satd. NH4PF6;

DOI:10.1021/ic0344822

Reference yield:

C18H16ClNO + 4-(aminomethyl)-2,6-bis([(2-hydroxybenzyl)(pyridin-2-ylmethyl)amino]methyl)phenol (630393-56-5) → 5-(acridin-9-yl)-N-(3,5-bis{[(2-hydroxybenzyl)(pyridin-2-yl)methylamino]methyl}-4-hydroxybenzyl)pentanamide (1123534-33-7)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃;

DOI:10.1002/ejic.200700383

upstream raw materials:

2-(4-hydroxy-3,5-bis{[(2-hydroxybenzyl)pyridin-2-ylmethylamino]methyl}benzyl)isoindole-1,3-dione

Downstream raw materials:

5-(acridin-9-yl)-N-(3,5-bis{[(2-hydroxybenzyl)(pyridin-2-yl)methylamino]methyl}-4-hydroxybenzyl)pentanamide