(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

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Chemical Name:(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate
CAS No.:1103935-84-7
Molecular Formula:C₇₅H₁₀₂O₁₆SSi
Molecular Weight:1319.78
Hs Code.:

(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

Synonyms:(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

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Chemical Property of (E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

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Technology Process of (E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

There total 1 articles about (E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1103935-92-7
C₇₅H₁₀₄O₁₇SSi

: 1103935-84-7
(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol8027253

Reference yield: 87.0%

: 1028481-99-3
(2E,4E)-octa-2,4-dienoic anhydride

: 1103935-84-7
(E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate

: 1103935-85-8
(2E,4E)-((2S,3S,6S,E)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)tetrahydro-2H-pyran-3-yl) octa-2,4-dienoate

Guidance literature:: (E)-methyl 2-((2S,6S)-2-((E)-4-((2R,6S)-6-(((2S,4S,6S)-4-acetoxy-6-((R)-2-(tert-butyldiphenylsilyloxy)-4-(tert-butylthio)-4-oxobutyl)-2-methoxy-3,3-dimethyltetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(4-methoxybenzyloxy)butyl)-2-methoxy-3-oxo-2H-pyran-4(3H,5H,6H)-ylidene)acetate; With cerium(III) chloride heptahydrate; In methanol; at 20 ℃;

With methanol; sodium tetrahydroborate; at -42 - 0 ℃; for 4h;

(2E,4E)-octa-2,4-dienoic anhydride; With pyridine; dmap; In dichloromethane; at 20 ℃; for 12h; diastereoselective reaction;
DOI:10.1021/ol8027253