(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

Base Information

Chemical Name:(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate
CAS No.:918869-01-9
Molecular Formula:C₃₄H₄₂N₃O₇P
Molecular Weight:635.697
Hs Code.:

Synonyms:(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

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Chemical Property of (+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

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Technology Process of (+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

There total 7 articles about (+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 134963-85-2
(diisopropoxyphosphoryl)methyl trifluoromethanesulfonate

: 918869-00-8
(+/-)-1-{2-amino-3-[(4-methoxytrityl)oxy]propyl}pyrimidine-2,4(1H,3H)-dione

: 918869-01-9
(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1135/cccc20060015

Reference yield:

: benzoic acid 2-hydroxy-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester

: 918869-01-9
(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 21.43 g / pyridine / 2 h

2.1: NaN₃ / dimethylformamide / 100 °C

3.1: 7.44 g / NaOH / methanol

4.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

5.1: 1.76 g / NH₃ / methanol

6.1: Ph₃P / tetrahydrofuran

6.2: 88 percent / H₂O / tetrahydrofuran / 3 h / Heating

7.1: 85 percent / Et₃N / tetrahydrofuran / 5 h / 0 °C

With pyridine; sodium hydroxide; sodium azide; di-isopropyl azodicarboxylate; ammonia; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;
DOI:10.1135/cccc20060015

Reference yield:

: 918868-72-1
(+/-)-2-azido-3-[(4-methoxytrityl)oxy]propan-1-ol

: 918869-01-9
(+/-) diisopropyl {[(2-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-1-{[(4-methoxytrityl)oxy]methyl}ethyl)amino]methyl}phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: 1.76 g / NH₃ / methanol

3.1: Ph₃P / tetrahydrofuran

3.2: 88 percent / H₂O / tetrahydrofuran / 3 h / Heating

4.1: 85 percent / Et₃N / tetrahydrofuran / 5 h / 0 °C

With di-isopropyl azodicarboxylate; ammonia; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; 1.1: Mitsunobu reaction;
DOI:10.1135/cccc20060015