P-TOLYL TRIFLATE

Base Information

• Chemical Name: P-TOLYL TRIFLATE
• CAS No.: 29540-83-8
• Molecular Formula: C8H7 F3 O3 S
• Molecular Weight: 240.203
• Hs Code.: 2904909090
• Mol file: 29540-83-8.mol

Synonyms:Methanesulfonicacid, trifluoro-, 4-methylphenyl ester (9CI); Methanesulfonic acid, trifluoro-,p-tolyl ester (8CI); 4-Methylphenyl triflate; 4-Methylphenyltrifluoromethanesulfonate; 4-Tolyl triflate; 4-Tolyl trifluoromethanesulfonate;p-Tolyl triflate; p-Tolyl trifluoromethanesulfonate

Chemical Property of P-TOLYL TRIFLATE

Chemical Property:

• Vapor Pressure: 0.0242mmHg at 25°C
• Refractive Index: n20/D 1.441(lit.)
• Boiling Point: 115 °C50 mm Hg(lit.)
• Flash Point: 192 °F
• PSA: 51.75000
• Density: 1.342 g/mL at 25 °C(lit.)
• LogP: 3.30420

Purity/Quality:

98%,99%, ^*data from raw suppliers

p-Tolyl Trifluoromethanesulfonate >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25-34-40
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Tolyl trifluoromethanesulfonate is a useful research chemical.

Technology Process of P-TOLYL TRIFLATE

There total 19 articles about P-TOLYL TRIFLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

dimethylzinc + 4-bromophenyl trifluoromethanesulfonate (66107-30-0) → p-tolyl triflate (29540-83-8)

Guidance literature:

palladium diacetate; triphenyl-arsane;

DOI:10.1002/jlcr.1181

Reference yield: 98.0%

p-cresol (106-44-5) + trifluoromethylsulfonic anhydride (358-23-6) → p-tolyl triflate (29540-83-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.joc.0c00491

Reference yield: 92.0%

p-cresol (106-44-5) + trifluorormethanesulfonic acid (1493-13-6) → p-tolyl triflate (29540-83-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00313

upstream raw materials:

p-cresol

trifluoromethylsulfonic anhydride

trifluorormethanesulfonic acid

4-methylbenzenediazonium tetrafluoroborate

Downstream raw materials:

2,5-dioxopyrrolidin-1-yl 4-methylbenzoate

N-cyclohexyl-p-toluidine

4-tolyl phenyl sulfide

1-methyl-4-n-pentylbenzene

Refernces

• 1、 Qin, Jian,Zhu, Shengqing,Chu, Lingling. "Dual Photoredox-/Palladium-Catalyzed Cross-Electrophile Couplings of Polyfluoroarenes with Aryl Halides and Triflates". supporting information. p. 2246 - 2252. Retrieved 2021/04/02.
• 2、 Guo, Peng,Wang, Ke,Jin, Wen-Jie,Xie, Hao,Qi, Liangliang,Liu, Xue-Yuan,Shu, Xing-Zhong. "Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis". supporting information. p. 513 - 523. Retrieved 2021/01/12.