Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Base Information

• Chemical Name: Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine
• CAS No.: 291306-42-8
• Molecular Formula: C₂₄H₂₇Cl₂NO₄
• Molecular Weight: 464.389
• Mol file: 291306-42-8.mol

Synonyms:Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Chemical Property of Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

There total 1 articles about Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Cis-(1S)-N-methyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-22-4) + di-tert-butyl dicarbonate (24424-99-5) → Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-42-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-42-8) → (5S,8S)-8-(tert-butoxycarbonyl(methyl)amino)-5-(3,4-dichlorophenyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid (291306-43-9)

Guidance literature:

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; With lithium hydroxide; water; In methanol; for 1.5h; Heating / reflux;

With hydrogenchloride; In methanol; pH=3 - 4;

Reference yield:

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine (291306-42-8) → tert-butyl (1S,4S)-4-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate (1204514-17-9)

Guidance literature:

Cis-(1S)-N-methyl-N-tert-butoxycarbonyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

With water; rochelle salt; sodium hydroxide; In tetrahydrofuran;

upstream raw materials:

Cis-(1S)-N-methyl-7-(methoxycarbonyl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine

di-tert-butyl dicarbonate

Downstream raw materials:

(5S,8S)-8-(tert-butoxycarbonyl(methyl)amino)-5-(3,4-dichlorophenyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

tert-butyl (1S,4S)-4-(3,4-dichlorophenyl)-7-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-yl(methyl)carbamate