5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]

Base Information

• Chemical Name: 5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]
• CAS No.: 143425-86-9
• Molecular Formula: C₁₆H₂₃N
• Molecular Weight: 229.365
• Mol file: 143425-86-9.mol

Synonyms:5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]

Chemical Property of 5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]

There total 1 articles about 5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-allyl-N-benzylcyclohexan-1-amine (123638-31-3) → 5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane] (143425-86-9) + trans-1-benzylamino-1-(propen-1-yl)cyclohexane

Guidance literature:

With sulfuric acid; In water; at 80 - 85 ℃; for 1.5h;

DOI:10.1007/BF02251709

Reference yield: 57.0%

5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane] (143425-86-9) + p-toluenesulfonyl chloride (98-59-9) → NC 00096199 (314039-27-5)

Guidance literature:

With sodium hydroxide; sodium carbonate; In dichloromethane; for 30h; Heating;

DOI:10.1023/A:1013805812281

Reference yield:

5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane] (143425-86-9) → 1-benzyl-5-methyl-1,2,4,5-tetrahydro-3H-spiro[benz-2-azepine-3,1'-cyclohexane]

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / crown ether DB-18-C-6; KMnO₄ / CH₂Cl₂ / 25 °C

2.1: Mg / diethyl ether

2.2: 68 percent / diethyl ether / 1 h / Heating

With potassium permanganate; crown ether DB-18-C-6; magnesium; In diethyl ether; dichloromethane;

DOI:10.1023/A:1013805812281

upstream raw materials:

1-allyl-N-benzylcyclohexan-1-amine

Downstream raw materials:

NC 00096199