Technology Process of 4-methoxy-3-[4-(5-methoxy-2-{(2-methoxy-4-hydroxymethyl)phenyl}phenethyl)phenoxy]benzaldehyde
There total 12 articles about 4-methoxy-3-[4-(5-methoxy-2-{(2-methoxy-4-hydroxymethyl)phenyl}phenethyl)phenoxy]benzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
tetrahydrofuran; water;
at 20 ℃;
for 12h;
DOI:10.1002/ejoc.201001023
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tetra-N-butylammonium tribromide; orthoformic acid triethyl ester / 6 h / 65 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 165 °C
3.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 0 - 20 °C
4.1: acetonitrile / 6 h / Reflux
4.2: 12 h / Reflux
5.1: 18-crown-6 ether; potassium carbonate / dichloromethane / 24 h / Reflux
6.1: 5% Pd(II)/C(eggshell); hydrogen; triethylamine / ethyl acetate / 24 h / 20 °C / 2250.23 Torr / Autoclave
7.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
With
hydrogenchloride; sodium tetrahydroborate; 18-crown-6 ether; 5% Pd(II)/C(eggshell); hydrogen; tetra-N-butylammonium tribromide; potassium carbonate; triethylamine; orthoformic acid triethyl ester;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
5.1: Wittig reaction;
DOI:10.1002/ejoc.201001023
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: -78 - 20 °C
1.3: 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethanol; water; toluene / 16 h / Inert atmosphere; Reflux
3.1: 18-crown-6 ether; potassium carbonate / dichloromethane / 24 h / Reflux
4.1: 5% Pd(II)/C(eggshell); hydrogen; triethylamine / ethyl acetate / 24 h / 20 °C / 2250.23 Torr / Autoclave
5.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; 18-crown-6 ether; 5% Pd(II)/C(eggshell); hydrogen; sodium carbonate; potassium carbonate; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; toluene;
2.1: Suzuki coupling / 3.1: Wittig reaction;
DOI:10.1002/ejoc.201001023
