N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide

Base Information

• Chemical Name: N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide
• CAS No.: 1026300-89-9
• Molecular Formula: C₂₂H₂₁N₃O₃S
• Molecular Weight: 407.493
• Mol file: 1026300-89-9.mol

Synonyms:N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide

Chemical Property of N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide

There total 4 articles about N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzylsulfanyl-N-(4-dimethylcarbamoyl-phenyl)-nicotinamide (1027145-44-3) → N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide (1026300-89-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/jm00045a012

Reference yield:

3-carboxy-2-mercaptopyridine (38521-46-9) → N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide (1026300-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / KOH / propan-2-ol; H₂O / 0.5 h / Heating

2: 1.) Et₃N, trimethylacetyl chloride / 1.) CH₂Cl₂, 45 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 21 h

3: 3-chloroperbenzoic acid / CH₂Cl₂ / 0.25 h / 0 °C

With potassium hydroxide; pivaloyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; isopropyl alcohol;

DOI:10.1021/jm00045a012

Reference yield:

benzyl chloride (100-44-7) → N-(4-Dimethylcarbamoyl-phenyl)-2-phenylmethanesulfinyl-nicotinamide (1026300-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / KOH / propan-2-ol; H₂O / 0.5 h / Heating

2: 1.) Et₃N, trimethylacetyl chloride / 1.) CH₂Cl₂, 45 deg C, 1 h, 2.) CH₂Cl₂, 25 deg C, 21 h

3: 3-chloroperbenzoic acid / CH₂Cl₂ / 0.25 h / 0 °C

With potassium hydroxide; pivaloyl chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; isopropyl alcohol;

DOI:10.1021/jm00045a012

upstream raw materials:

2-Benzylsulfanyl-N-(4-dimethylcarbamoyl-phenyl)-nicotinamide

3-carboxy-2-mercaptopyridine

benzyl chloride

2-benzylsulfanylnicotinic acid