4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine

Base Information

• Chemical Name: 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine
• CAS No.: 1050477-91-2
• Molecular Formula: C₃₁H₃₃FN₂O₂
• Molecular Weight: 484.614

Synonyms:4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine

Chemical Property of 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine

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Technology Process of 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine

There total 1 articles about 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-benzyl-4-(4-methoxybenzylamino)cyclohexanone (1050477-71-8) + 2-(5-fluoro-1H-indol-3-yl)ethanol (101349-12-6) → 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine (1050477-91-2)

Guidance literature:

4-benzyl-4-(4-methoxybenzylamino)cyclohexanone; 2-(5-fluoro-1H-indol-3-yl)ethanol; With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; Cooling with ice;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h;

Reference yield: 64.0%

4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine (1050477-91-2) → N-{6'-Fluoro-4',9'-dihydro-4-benzylspiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-yl}amine (1050477-90-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 40 ℃; for 7h; under 2250.23 Torr;

Reference yield: 41.0%

4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine (1050477-91-2) + citric acid (77-92-9,906507-37-7) → 4-benzyl-6'-fluoro-N-(4-methoxybenzyl)-4',9'-dihydro-3'h-spiro[cyclo-hexane-1,1'-pyrano[3,4-b]indol]-4-amine citrate

Guidance literature:

In ethanol;

upstream raw materials:

4-benzyl-4-(4-methoxybenzylamino)cyclohexanone

2-(5-fluoro-1H-indol-3-yl)ethanol

Downstream raw materials:

N-{6'-Fluoro-4',9'-dihydro-4-benzylspiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-yl}amine

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