L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide

Base Information

• Chemical Name: L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide
• CAS No.: 473578-24-4
• Molecular Formula: C₁₇H₁₈N₂O₄
• Molecular Weight: 314.341
• Mol file: 473578-24-4.mol

Synonyms:L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide

Chemical Property of L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide

There total 5 articles about L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-2-[(benzo[1,3]dioxol-5-ylmethylene)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide (473578-16-4) → L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide (473578-24-4)

Guidance literature:

With (polystyrylmethyl)trimethylammonium borohydride; In methanol; dichloromethane; for 4h;

DOI:10.1016/S0040-4020(02)00628-2

Reference yield:

(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate (26531-82-8) → L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide (473578-24-4)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 48 h / 45 °C

2: 95 percent / ethyl acetate; methanol / 1 h / 20 °C

3: 98 percent / (polystyrylmethyl)trimethylammonium borohydride / CH₂Cl₂; methanol / 4 h

With (polystyrylmethyl)trimethylammonium borohydride; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/S0040-4020(02)00628-2

Reference yield:

L-2-amino-2-(4'-hydroxyphenyl)-N-methylacetamide (168158-40-5) → L-2-[(benzo[1,3]dioxol-5-ylmethyl)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide (473578-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / ethyl acetate; methanol / 1 h / 20 °C

2: 98 percent / (polystyrylmethyl)trimethylammonium borohydride / CH₂Cl₂; methanol / 4 h

With (polystyrylmethyl)trimethylammonium borohydride; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/S0040-4020(02)00628-2

upstream raw materials:

L-2-[(benzo[1,3]dioxol-5-ylmethylene)amino]-2-(4'-hydroxyphenyl)-N-methylacetamide

(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

L-2-amino-2-(4'-hydroxyphenyl)-N-methylacetamide

piperonal

Downstream raw materials:

N-(benzo[1,3]dioxol-5-ylmethyl)-2,2,2-trifluoro-N-[(4-hydroxyphenyl)(methylcarbamoyl)methyl]acetamide