4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Base Information

Chemical Name:4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide
CAS No.:1579939-48-2
Molecular Formula:C₁₇H₁₇FN₆O₄S₂
Molecular Weight:452.49
Hs Code.:

Synonyms:4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

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Chemical Property of 4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

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Technology Process of 4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

There total 8 articles about 4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

: 1579939-47-1
C₂₁H₂₅FN₆O₄S₂

: 1579939-48-2
4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; at 0 - 20 ℃; for 24h;
DOI:10.1039/c3ob41936c

Reference yield:

: C₂₀H₂₄FN₅O₃S₂

: 1579939-48-2
4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / water; methanol / 4 h / 30 °C

2: trifluoroacetic acid / 24 h / 0 - 20 °C

With acetic acid; trifluoroacetic acid; In methanol; water;
DOI:10.1039/c3ob41936c

Reference yield:

: 99987-05-0
4-tert-butylsulfamoyl-benzoic acid

: 1579939-48-2
4-(4-(4-fluorophenyl)-5-(2-(1-hydroxyureido)ethylthio)-4H-1,2,4-triazol-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrazine hydrate / ethanol / 6 h / Reflux

3.1: ethanol / 5 h / Reflux

4.1: sodium hydroxide / methanol / 2 h / Reflux

4.2: pH 2

5.1: potassium carbonate / acetone / 0.5 h / 50 °C

5.2: 3 h / Reflux

6.1: sodium cyanoborohydride; methyl orange / methanol; tetrahydrofuran / 0.08 h / 30 °C

6.2: 4 h / 30 °C

7.1: acetic acid / water; methanol / 4 h / 30 °C

8.1: trifluoroacetic acid / 24 h / 0 - 20 °C

With methyl orange; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1039/c3ob41936c