Technology Process of 1-(4-methoxyphenyl)-6-[4-(2-oxo-1-piperidinyl)phenyl]-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one
There total 6 articles about 1-(4-methoxyphenyl)-6-[4-(2-oxo-1-piperidinyl)phenyl]-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; trifluoroacetic acid;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N,N-dimethyl-formamide; oxalyl dichloride; pyridine / acetonitrile / 2 h / 0 - 20 °C
2: tributyltin chloride; sodium azide / tetrahydrofuran / 0 °C / Reflux
3: toluene / 20 °C
4: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 60 °C / Inert atmosphere
5: trifluoroacetic acid; water / tetrahydrofuran / 20 °C
With
pyridine; sodium azide; oxalyl dichloride; tributyltin chloride; water; palladium diacetate; caesium carbonate; N,N-dimethyl-formamide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; palladium diacetate; caesium carbonate / 1,4-dioxane / 60 °C / Inert atmosphere
2: trifluoroacetic acid; water / tetrahydrofuran / 20 °C
With
water; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
tetrahydrofuran; 1,4-dioxane;