2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

Base Information

Chemical Name:2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride
CAS No.:1403385-02-3
Molecular Formula:C₂₉H₃₂ClN₃O₃*ClH
Molecular Weight:542.505
Hs Code.:

Synonyms:2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

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Chemical Property of 2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

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Technology Process of 2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

There total 8 articles about 2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403385-25-0
2-(dimethylamino)ethyl 4-((2S,4R)-1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

: 1403385-02-3
2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; Inert atmosphere;

Reference yield:

: 1300031-94-0
1-methylethyl {(3S)-3-[(4-bromophenyl)amino]butanoyl}carbamate

: 1403385-02-3
2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium tetrahydroborate; magnesium(II) chloride hexahydrate / ethanol; water / 2 h / -10 - 20 °C

2.1: pyridine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 105 °C / Inert atmosphere

4.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 6 °C

4.2: 0.51 h / 0 °C

5.1: sodium t-butanolate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 70 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

7.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.08 h

7.2: 20 °C

8.1: hydrogenchloride / dichloromethane; diethyl ether / Inert atmosphere

With pyridine; hydrogenchloride; dmap; aluminum (III) chloride; sodium tetrahydroborate; magnesium(II) chloride hexahydrate; water; sodium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DavePhos; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1300031-98-4
1-methylethyl [(2S,4R)-1-acetyl-6-bromo-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

: 1403385-02-3
2-(dimethylamino)ethyl 4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzoate monohydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 105 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 0.33 h / 0 - 6 °C

2.2: 0.51 h / 0 °C

3.1: sodium t-butanolate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 70 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol / 2 h / 20 °C

5.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0.08 h

5.2: 20 °C

6.1: hydrogenchloride / dichloromethane; diethyl ether / Inert atmosphere

With hydrogenchloride; dmap; aluminum (III) chloride; water; sodium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; DavePhos; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; toluene;