(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

Base Information

Chemical Name:(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate
CAS No.:950901-99-2
Molecular Formula:C₂₈H₄₀O₅Si
Molecular Weight:484.708
Hs Code.:

Synonyms:(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

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Chemical Property of (+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

Chemical Property:

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Technology Process of (+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

There total 4 articles about (+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 125476-54-2
(-)-2-(ethoxycarbonyl)-3-hydroxypropyl hexanoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 950901-99-2
(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1002/hlca.200790144

Reference yield:

: 950902-17-7
ethyl 3-[(tert-butyl)dimethylsilyloxy]-2-{[(tert-butyl)dimethylsilyloxy]methyl}propanoate

: 950901-99-2
(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

2: 85 percent / DMAP / CH₂Cl₂ / 4.5 h / 20 °C

3: porcine pancreas lipase; aq. NaOH / aq. phosphate buffer; tetrahydrofuran / 7 h / 30 °C / pH 6.9 - 7.1

4: 93 percent / 1H-imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; Porcine Pancreas Lipase; tetrabutyl ammonium fluoride; In tetrahydrofuran; phosphate buffer; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200790144

Reference yield:

: 99116-11-7
3-Hydroxy-2-(hydroxymethyl)propionsaeure-ethylester

: 950901-99-2
(+)-(S)-3-[(tert-butyl)diphenylsilyloxy]-2-(ethoxycarbonyl)propyl hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / DMAP / CH₂Cl₂ / 4.5 h / 20 °C

2: porcine pancreas lipase; aq. NaOH / aq. phosphate buffer; tetrahydrofuran / 7 h / 30 °C / pH 6.9 - 7.1

3: 93 percent / 1H-imidazole / dimethylformamide / 1 h / 20 °C

With 1H-imidazole; dmap; sodium hydroxide; Porcine Pancreas Lipase; In tetrahydrofuran; phosphate buffer; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200790144