(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

Base Information

Chemical Name:(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)
CAS No.:1450923-80-4
Molecular Formula:C₄₉H₄₂F₉N₃O₁₀S₂
Molecular Weight:1068
Hs Code.:

(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

Synonyms:(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

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Chemical Property of (2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

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Technology Process of (2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

There total 5 articles about (2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450923-81-5
C₂₉H₂₈F₃N₃O₆S₂

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 1450923-80-4
(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

Guidance literature:: With dmap; triethylamine; In dichloromethane;

Reference yield:

: 1450923-46-2
4-(2-bromo-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

: 1450923-80-4
(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere

2: 4-methylmorpholine N-oxide / tetrahydrofuran; water / 3 h / 20 °C

3: triethylamine; dmap / dichloromethane

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1450923-24-6
N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

: 1450923-80-4
(2S,2'S)-3-(2-(7-(N-(4-methoxybenzyl)-N-(thiazol-2-yl)sulfamoyl)-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)phenyl)propane-1,2-diyl bis(3,3,3-trifluoro-2-methoxy-2-phenylpropanoate)

Guidance literature:: Multi-step reaction with 4 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium t-butanolate / toluene / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Inert atmosphere

3: 4-methylmorpholine N-oxide / tetrahydrofuran; water / 3 h / 20 °C

4: triethylamine; dmap / dichloromethane

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-methylmorpholine N-oxide; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;