tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate
CAS No.:145525-25-3
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

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Chemical Property of tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

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Technology Process of tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

There total 16 articles about tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 145525-26-4
tert-butyl ((S)-1-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

: 145525-25-3
tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -70 ℃; for 0.25h;

Reference yield: 76.0%

: 20902-47-0
N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester

: 145525-25-3
tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.04.031

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 145525-25-3
tert-butyl ((S)-3-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NEt₃, n-propyl phosphonic acid anhydride / CH₂Cl₂; ethyl acetate / 3 h / 0 - 20 °C

2: 88 percent / oxalyl chloride, DMSO, NEt₃ / CH₂Cl₂ / 0.25 h / -70 °C

With oxalyl dichloride; propylphosphonic anhydride; dimethyl sulfoxide; triethylamine; In dichloromethane; ethyl acetate;